The position at the transcription start site is designated +1, the sequence downstream from +1 will carry a "+" sign, and will appear in mRNA. Any sequence upstream from "+1" will carry a "-" sign, this sequence often contains promter and enhancer sequences. The first base will be "-1", and the number will increase as it is farther away from the "+1". So "-72" will be closer to the "+1" site than the "-205".
The terms "upstream" and "downstream" are only relative terms. As in case you are standing in the middle of a river, upstream is the part of river where water is coming towards you, and downstream is where water is moving away from you. Depending on where you are standing, the reference of "upstream" and "downstream" can be changed.
The "5'-region" is also a nonspecific term. When you mean 5'-end of mRNA, it is the beginning of the transcript, starting from "+1".
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