AstraZeneca is looking for a Biotransformation Scientist in

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AstraZeneca is looking for a Biotransformation Scientist in

Postby Express » Sep 25 2014 7:46 am

Business Area Research and Development
Specialism Innovative Medicines
Department Oncology iMed
Location Cambridge
Closing date for applications 15 October 2014


Astrazeneca are looking for an experienced Biotransformation Scientist. The specific opportunity is in the Oncology Biotransformation Team where we are looking for a successful met-id scientist to join our advanced capability. The role will be based in Cambridge but will require some commuting to Alderley Park, Cheshire, on a flexible basis.

• The role is within the Oncology iMED's Design and ADME group.
• This is a diverse group within the DMPK section of Oncology iScience that delivers Biotransformation, in-vitro/in-vivo ADME and PD Bioanalysis experimental work as well as DMPK focussed drug design support to project teams.

Salary - Competitive


• Responsible for delivering quality in-vitro and in-vivo Biotransformation data to support small molecule projects from target selection to registration and LCM.
• Routinely work with clinical teams and external partners to ensure excellent study design and timely reporting of high quality biotransformation regulatory studies.
• Provide the team with excellent analytical, mass spectrometry and metabolite identification skills with a strong focus on project delivery and independent working.
• Plan and deliver bespoke met-id packages for projects, working with project representatives and colleagues to answer key questions and satisfy regulatory requirements robustly and efficiently using the latest analytical techniques and DMPK strategies.
• Become a recognised source of Biotransformation expertise in the iMED and AZ, particularly in the drug development phase of the business.
• Be responsible for the operation, maintenance and troubleshooting of high resolution, accurate mass instrumentation.
• Contribute to collaborative research aligned to DMPK and Oncology objectives.
• Bring a fresh perspective into the group and the enthusiasm to tackle new challenges and learn new skills.
Minimum Requirements - Education and Experience

• Degree in Chemistry/Biochemistry with 5 years directly relevant industrial experience or 3 years experience and a higher degree in a research area directly linked to analytical science.

Skills & Capabilities

• Extensive experience of structural elucidation of small molecules through the generation and interpretation of high resolution mass spectra, ideally with a focus on metabolite identification and experience of using radiolabeled compounds.
• A strong understanding of how metabolite identification studies are carried out in drug development e.g. MIST and hADME studies, how to work with in-vitro colleagues to optimise results and what it takes to provide a regulatory met-id package in the most efficient way is essential.
• Significant experience of influencing drug development strategies for Biotransformation studies and generating regulatory documents to feed into project submissions.
• Can-do attitude with the ability to work independently to Good Laboratory Standards (GLS), HTA and Radiochemical compliance with minimal direction from line or project leaders.
• Track record of successful problem solving, high quality science and influencing of stakeholders, particularly in a drug project context.
• Good understanding of the drug discovery process and how DMPK studies contribute to that process.
• Desire to carry out scientific development and research work with a view to publishing collaboratively.
• Proven ability to work with Thermo scientific FT orbitrap mass spectrometers such as the LTQ- orbitrap XL, Q-Exactive or Orbitrap fusion would be advantageous as would experience of at least one of the following elements:
o hADME study delivery and/or dosimetry calculations.
o Use of laboratory automation platforms.
o Regulatory reporting and GLP.
o Line and/or capability management.

• Can-do attitude and a desire to learn and adapt is essential.
• Strong customer focus with the ability to have robust discussions with project leaders to ensure that project, scientific and resource demands are aligned.
• Depending on the skills and experience of the candidate this role may be offered at the Senior or Associate Principle Scientist levels.

Deadline for applications - 15th of October 2014
Additional Website Text

• Laboratory based role split across Cambridge and Alderley Park until 2017.
• No line reports.
• Part of a group of 13 and sub-team of 3
• Depending on their skills and experience the successful candidate may be able to take on significant leadership of the global Oncology Biotransformation capability.
• Opportunities to supervise and coach modern apprentices and sandwich students.

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